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About The Journal

Journal of Organic Chemistry: Synthesis and Process Development (JOCS) is a broad field of organic chemistry, and its related disciplines are Synthetic Organic Chemistry, medicinal chemistry, and pharmaceutical chemistry. JOCS publishes rapid publication of original research articles, reviews, book chapters, short communications, rapid communications, and abstracts. Rapid communications and abstracts of such research preserve their research work and to transmit their new contributions to the research community and quickly to other researchers and to the public. Process chemistry is the branch of pharmaceutical chemistry deal with the development and optimization of a synthetic scheme and pilot plant procedure to manufacture compounds for the drug development phase. Process chemistry is distinguished from medicinal chemistry, which is the disciplines of pharmaceutical chemistry tasked with designing and synthesizing molecules on small scale in the early drug discovery phase. And medicinal chemists are largely concerned with synthesizing a large number of compounds as quickly as possible from easily tunable chemical building blocks for SAR studies. In general, the repertoire of reactions utilized in discovery chemistry is somewhat narrow for example; the Buchwald-Hartwig amination, Grub’s catalytic reaction, Click Chemistry, Suzuki coupling and reductive amination are commonplace reactions. In contrast, process chemists are tasked with identifying a chemical process that is safe, cost and labor efficient, “green,” and reproducible, among other considerations. Oftentimes, in searching for the shortest, most efficient synthetic route, process chemists must devise creative synthetic solutions that eliminate costly functional group manipulations steps. Process synthetic routes should be designed such that atom economy is maximized for the entire synthetic scheme. Consequently, “costly” reagents such as protecting groups and high molecular weight leaving groups should be avoided where possible. An atom economy value in the range of 70 to 90 percent for an API synthesis is ideal depends on the nature of the reactions, however some processes can also lesser percentage of yield also acceptable provided they are safe and eco-friendly in nature, and it may be impractical or impossible to access certain complex targets within this range. Nevertheless, atom economy is a good metric to compare two routes to the same molecule.

Aim and Scope

Sciforce Joournal of Organic Chemistry: Synthesis and Process Development (JOCS)  journals and research papers are a gateway to the community of Agriculture & Horticulture Research experts, researchers and peers. While adhering to the international standards of online publishing, JOCS aims to publish high quality, informative, scientific and well-researched content.

Journal of Organic Chemistry: Synthesis and Process Development